The first double-blind, randomised, parallel-group certolizumab pegol study in methotrexate-naive early rheumatoid arthritis patients with poor prognostic factors, C-OPERA, shows inhibition of radiographic progression.
Identifieur interne : 000011 ( Main/Exploration ); précédent : 000010; suivant : 000012The first double-blind, randomised, parallel-group certolizumab pegol study in methotrexate-naive early rheumatoid arthritis patients with poor prognostic factors, C-OPERA, shows inhibition of radiographic progression.
Auteurs : Tatsuya Atsumi [Japon] ; Kazuhiko Yamamoto [Japon] ; Tsutomu Takeuchi [Japon] ; Hisashi Yamanaka [Japon] ; Naoki Ishiguro [Japon] ; Yoshiya Tanaka [Japon] ; Katsumi Eguchi [Japon] ; Akira Watanabe [Japon] ; Hideki Origasa [Japon] ; Shinsuke Yasuda [Japon] ; Yuji Yamanishi [Japon] ; Yasuhiko Kita [Japon] ; Tsukasa Matsubara [Japon] ; Masahiro Iwamoto [Japon] ; Toshiharu Shoji [Japon] ; Toshiyuki Okada [Japon] ; Désirée Van Der Heijde [Pays-Bas] ; Nobuyuki Miyasaka [Japon] ; Takao Koike [Japon]Source :
- Annals of the rheumatic diseases ; 2016.
English descriptors
- KwdEn :
- Adult, Antibodies (blood), Antirheumatic Agents (adverse effects), Antirheumatic Agents (therapeutic use), Arthritis, Rheumatoid (blood), Arthritis, Rheumatoid (drug therapy), Arthritis, Rheumatoid (radiography), Blood Sedimentation, Certolizumab Pegol (adverse effects), Certolizumab Pegol (therapeutic use), Double-Blind Method, Drug Therapy, Combination (adverse effects), Female, Humans, Male, Methotrexate (adverse effects), Methotrexate (therapeutic use), Middle Aged, Peptides, Cyclic (immunology), Prognosis, Remission Induction, Rheumatoid Factor (blood), Severity of Illness Index, Treatment Outcome.
- MESH :
- chemical , adverse effects : Antirheumatic Agents, Certolizumab Pegol, Methotrexate.
- chemical , blood : Antibodies, Rheumatoid Factor.
- chemical , immunology : Peptides, Cyclic.
- chemical , therapeutic use : Antirheumatic Agents, Certolizumab Pegol, Methotrexate.
- adverse effects : Drug Therapy, Combination.
- blood : Arthritis, Rheumatoid.
- drug therapy : Arthritis, Rheumatoid.
- radiography : Arthritis, Rheumatoid.
- Adult, Blood Sedimentation, Double-Blind Method, Female, Humans, Male, Middle Aged, Prognosis, Remission Induction, Severity of Illness Index, Treatment Outcome.
Abstract
To evaluate efficacy and safety of combination therapy using certolizumab pegol (CZP) and methotrexate (MTX) as first-line treatment for MTX-naive, early rheumatoid arthritis (RA) with poor prognostic factors, compared with MTX alone.
DOI: 10.1136/annrheumdis-2015-207511
PubMed: 26139005
Affiliations:
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Tōhoku</region></placeName></affiliation></author><author><name sortKey="Origasa, Hideki" sort="Origasa, Hideki" uniqKey="Origasa H" first="Hideki" last="Origasa">Hideki Origasa</name><affiliation wicri:level="1"><nlm:affiliation>University of Toyama School of Medicine, Toyama, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>University of Toyama School of Medicine, Toyama</wicri:regionArea><wicri:noRegion>Toyama</wicri:noRegion></affiliation></author><author><name sortKey="Yasuda, Shinsuke" sort="Yasuda, Shinsuke" uniqKey="Yasuda S" first="Shinsuke" last="Yasuda">Shinsuke Yasuda</name><affiliation wicri:level="1"><nlm:affiliation>Hokkaido University Graduate School of Medicine, Sapporo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Hokkaido University Graduate School of Medicine, Sapporo</wicri:regionArea><wicri:noRegion>Sapporo</wicri:noRegion></affiliation></author><author><name sortKey="Yamanishi, Yuji" sort="Yamanishi, Yuji" uniqKey="Yamanishi Y" first="Yuji" last="Yamanishi">Yuji Yamanishi</name><affiliation wicri:level="1"><nlm:affiliation>Hiroshima Rheumatology Clinic, Hiroshima, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Hiroshima Rheumatology Clinic, Hiroshima</wicri:regionArea><wicri:noRegion>Hiroshima</wicri:noRegion></affiliation></author><author><name sortKey="Kita, Yasuhiko" sort="Kita, Yasuhiko" uniqKey="Kita Y" first="Yasuhiko" last="Kita">Yasuhiko Kita</name><affiliation wicri:level="1"><nlm:affiliation>Yokohama Rosai Hospital, Yokohama, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Yokohama Rosai Hospital, Yokohama</wicri:regionArea><wicri:noRegion>Yokohama</wicri:noRegion></affiliation></author><author><name sortKey="Matsubara, Tsukasa" sort="Matsubara, Tsukasa" uniqKey="Matsubara T" first="Tsukasa" last="Matsubara">Tsukasa Matsubara</name><affiliation wicri:level="1"><nlm:affiliation>Matsubara Mayflower Hospital, Kato, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Matsubara Mayflower Hospital, Kato</wicri:regionArea><wicri:noRegion>Kato</wicri:noRegion></affiliation></author><author><name sortKey="Iwamoto, Masahiro" sort="Iwamoto, Masahiro" uniqKey="Iwamoto M" first="Masahiro" last="Iwamoto">Masahiro Iwamoto</name><affiliation wicri:level="1"><nlm:affiliation>Jichi Medical University, Tochigi, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Jichi Medical University, Tochigi</wicri:regionArea><wicri:noRegion>Tochigi</wicri:noRegion></affiliation></author><author><name sortKey="Shoji, Toshiharu" sort="Shoji, Toshiharu" uniqKey="Shoji T" first="Toshiharu" last="Shoji">Toshiharu Shoji</name><affiliation wicri:level="3"><nlm:affiliation>UCB Pharma, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>UCB Pharma, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Okada, Toshiyuki" sort="Okada, Toshiyuki" uniqKey="Okada T" first="Toshiyuki" last="Okada">Toshiyuki Okada</name><affiliation wicri:level="3"><nlm:affiliation>Astellas Pharma Inc., Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Astellas Pharma Inc., Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Van Der Heijde, Desiree" sort="Van Der Heijde, Desiree" uniqKey="Van Der Heijde D" first="Désirée" last="Van Der Heijde">Désirée Van Der Heijde</name><affiliation wicri:level="3"><nlm:affiliation>Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Rheumatology, Leiden University Medical Centre, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Miyasaka, Nobuyuki" sort="Miyasaka, Nobuyuki" uniqKey="Miyasaka N" first="Nobuyuki" last="Miyasaka">Nobuyuki Miyasaka</name><affiliation wicri:level="3"><nlm:affiliation>Tokyo Medical and Dental University, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo Medical and Dental University, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Koike, Takao" sort="Koike, Takao" uniqKey="Koike T" first="Takao" last="Koike">Takao Koike</name><affiliation wicri:level="1"><nlm:affiliation>Hokkaido University Graduate School of Medicine, Sapporo, Japan NTT Sapporo Medical Centre, Sapporo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Hokkaido University Graduate School of Medicine, Sapporo, Japan NTT Sapporo Medical Centre, Sapporo</wicri:regionArea><wicri:noRegion>Sapporo</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26139005</idno><idno type="pmid">26139005</idno><idno type="doi">10.1136/annrheumdis-2015-207511</idno><idno type="wicri:Area/PubMed/Corpus">000068</idno><idno type="wicri:Area/PubMed/Curation">000068</idno><idno type="wicri:Area/PubMed/Checkpoint">000006</idno><idno type="wicri:Area/Ncbi/Merge">000D75</idno><idno type="wicri:Area/Ncbi/Curation">000D75</idno><idno type="wicri:Area/Ncbi/Checkpoint">000D75</idno><idno type="wicri:Area/Main/Merge">000011</idno><idno type="wicri:Area/Main/Curation">000011</idno><idno type="wicri:Area/Main/Exploration">000011</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The first double-blind, randomised, parallel-group certolizumab pegol study in methotrexate-naive early rheumatoid arthritis patients with poor prognostic factors, C-OPERA, shows inhibition of radiographic progression.</title><author><name sortKey="Atsumi, Tatsuya" sort="Atsumi, Tatsuya" uniqKey="Atsumi T" first="Tatsuya" last="Atsumi">Tatsuya Atsumi</name><affiliation wicri:level="1"><nlm:affiliation>Hokkaido University Graduate School of Medicine, Sapporo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Hokkaido University Graduate School of Medicine, Sapporo</wicri:regionArea><wicri:noRegion>Sapporo</wicri:noRegion></affiliation></author><author><name sortKey="Yamamoto, Kazuhiko" sort="Yamamoto, Kazuhiko" uniqKey="Yamamoto K" first="Kazuhiko" last="Yamamoto">Kazuhiko Yamamoto</name><affiliation wicri:level="3"><nlm:affiliation>The University of Tokyo, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Takeuchi, Tsutomu" sort="Takeuchi, Tsutomu" uniqKey="Takeuchi T" first="Tsutomu" last="Takeuchi">Tsutomu Takeuchi</name><affiliation wicri:level="3"><nlm:affiliation>Keio University School of Medicine, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Keio University School of Medicine, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Yamanaka, Hisashi" sort="Yamanaka, Hisashi" uniqKey="Yamanaka H" first="Hisashi" last="Yamanaka">Hisashi Yamanaka</name><affiliation wicri:level="3"><nlm:affiliation>Tokyo Women's Medical University, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo Women's Medical University, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Ishiguro, Naoki" sort="Ishiguro, Naoki" uniqKey="Ishiguro N" first="Naoki" last="Ishiguro">Naoki Ishiguro</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, Nagoya University Graduate School, Nagoya, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Faculty of Medicine, Nagoya University Graduate School, Nagoya</wicri:regionArea><wicri:noRegion>Nagoya</wicri:noRegion></affiliation></author><author><name sortKey="Tanaka, Yoshiya" sort="Tanaka, Yoshiya" uniqKey="Tanaka Y" first="Yoshiya" last="Tanaka">Yoshiya Tanaka</name><affiliation wicri:level="1"><nlm:affiliation>University of Occupational and Environmental Health, Kitakyushu, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>University of Occupational and Environmental Health, Kitakyushu</wicri:regionArea><wicri:noRegion>Kitakyushu</wicri:noRegion></affiliation></author><author><name sortKey="Eguchi, Katsumi" sort="Eguchi, Katsumi" uniqKey="Eguchi K" first="Katsumi" last="Eguchi">Katsumi Eguchi</name><affiliation wicri:level="1"><nlm:affiliation>Sasebo Chuo Hospital, Nagasaki, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Sasebo Chuo Hospital, Nagasaki</wicri:regionArea><wicri:noRegion>Nagasaki</wicri:noRegion></affiliation></author><author><name sortKey="Watanabe, Akira" sort="Watanabe, Akira" uniqKey="Watanabe A" first="Akira" last="Watanabe">Akira Watanabe</name><affiliation wicri:level="4"><nlm:affiliation>Tohoku University, Sendai, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Tohoku University, Sendai</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation></author><author><name sortKey="Origasa, Hideki" sort="Origasa, Hideki" uniqKey="Origasa H" first="Hideki" last="Origasa">Hideki Origasa</name><affiliation wicri:level="1"><nlm:affiliation>University of Toyama School of Medicine, Toyama, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>University of Toyama School of Medicine, Toyama</wicri:regionArea><wicri:noRegion>Toyama</wicri:noRegion></affiliation></author><author><name sortKey="Yasuda, Shinsuke" sort="Yasuda, Shinsuke" uniqKey="Yasuda S" first="Shinsuke" last="Yasuda">Shinsuke Yasuda</name><affiliation wicri:level="1"><nlm:affiliation>Hokkaido University Graduate School of Medicine, Sapporo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Hokkaido University Graduate School of Medicine, Sapporo</wicri:regionArea><wicri:noRegion>Sapporo</wicri:noRegion></affiliation></author><author><name sortKey="Yamanishi, Yuji" sort="Yamanishi, Yuji" uniqKey="Yamanishi Y" first="Yuji" last="Yamanishi">Yuji Yamanishi</name><affiliation wicri:level="1"><nlm:affiliation>Hiroshima Rheumatology Clinic, Hiroshima, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Hiroshima Rheumatology Clinic, Hiroshima</wicri:regionArea><wicri:noRegion>Hiroshima</wicri:noRegion></affiliation></author><author><name sortKey="Kita, Yasuhiko" sort="Kita, Yasuhiko" uniqKey="Kita Y" first="Yasuhiko" last="Kita">Yasuhiko Kita</name><affiliation wicri:level="1"><nlm:affiliation>Yokohama Rosai Hospital, Yokohama, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Yokohama Rosai Hospital, Yokohama</wicri:regionArea><wicri:noRegion>Yokohama</wicri:noRegion></affiliation></author><author><name sortKey="Matsubara, Tsukasa" sort="Matsubara, Tsukasa" uniqKey="Matsubara T" first="Tsukasa" last="Matsubara">Tsukasa Matsubara</name><affiliation wicri:level="1"><nlm:affiliation>Matsubara Mayflower Hospital, Kato, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Matsubara Mayflower Hospital, Kato</wicri:regionArea><wicri:noRegion>Kato</wicri:noRegion></affiliation></author><author><name sortKey="Iwamoto, Masahiro" sort="Iwamoto, Masahiro" uniqKey="Iwamoto M" first="Masahiro" last="Iwamoto">Masahiro Iwamoto</name><affiliation wicri:level="1"><nlm:affiliation>Jichi Medical University, Tochigi, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Jichi Medical University, Tochigi</wicri:regionArea><wicri:noRegion>Tochigi</wicri:noRegion></affiliation></author><author><name sortKey="Shoji, Toshiharu" sort="Shoji, Toshiharu" uniqKey="Shoji T" first="Toshiharu" last="Shoji">Toshiharu Shoji</name><affiliation wicri:level="3"><nlm:affiliation>UCB Pharma, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>UCB Pharma, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Okada, Toshiyuki" sort="Okada, Toshiyuki" uniqKey="Okada T" first="Toshiyuki" last="Okada">Toshiyuki Okada</name><affiliation wicri:level="3"><nlm:affiliation>Astellas Pharma Inc., Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Astellas Pharma Inc., Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Van Der Heijde, Desiree" sort="Van Der Heijde, Desiree" uniqKey="Van Der Heijde D" first="Désirée" last="Van Der Heijde">Désirée Van Der Heijde</name><affiliation wicri:level="3"><nlm:affiliation>Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Rheumatology, Leiden University Medical Centre, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Miyasaka, Nobuyuki" sort="Miyasaka, Nobuyuki" uniqKey="Miyasaka N" first="Nobuyuki" last="Miyasaka">Nobuyuki Miyasaka</name><affiliation wicri:level="3"><nlm:affiliation>Tokyo Medical and Dental University, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo Medical and Dental University, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Koike, Takao" sort="Koike, Takao" uniqKey="Koike T" first="Takao" last="Koike">Takao Koike</name><affiliation wicri:level="1"><nlm:affiliation>Hokkaido University Graduate School of Medicine, Sapporo, Japan NTT Sapporo Medical Centre, Sapporo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Hokkaido University Graduate School of Medicine, Sapporo, Japan NTT Sapporo Medical Centre, Sapporo</wicri:regionArea><wicri:noRegion>Sapporo</wicri:noRegion></affiliation></author></analytic><series><title level="j">Annals of the rheumatic diseases</title><idno type="e-ISSN">1468-2060</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antibodies (blood)</term><term>Antirheumatic Agents (adverse effects)</term><term>Antirheumatic Agents (therapeutic use)</term><term>Arthritis, Rheumatoid (blood)</term><term>Arthritis, Rheumatoid (drug therapy)</term><term>Arthritis, Rheumatoid (radiography)</term><term>Blood Sedimentation</term><term>Certolizumab Pegol (adverse effects)</term><term>Certolizumab Pegol (therapeutic use)</term><term>Double-Blind Method</term><term>Drug Therapy, Combination (adverse effects)</term><term>Female</term><term>Humans</term><term>Male</term><term>Methotrexate (adverse effects)</term><term>Methotrexate (therapeutic use)</term><term>Middle Aged</term><term>Peptides, Cyclic (immunology)</term><term>Prognosis</term><term>Remission Induction</term><term>Rheumatoid Factor (blood)</term><term>Severity of Illness Index</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antirheumatic Agents</term><term>Certolizumab Pegol</term><term>Methotrexate</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies</term><term>Rheumatoid Factor</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Peptides, Cyclic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antirheumatic Agents</term><term>Certolizumab Pegol</term><term>Methotrexate</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Drug Therapy, Combination</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Arthritis, Rheumatoid</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Arthritis, Rheumatoid</term></keywords><keywords scheme="MESH" qualifier="radiography" xml:lang="en"><term>Arthritis, Rheumatoid</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Blood Sedimentation</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prognosis</term><term>Remission Induction</term><term>Severity of Illness Index</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To evaluate efficacy and safety of combination therapy using certolizumab pegol (CZP) and methotrexate (MTX) as first-line treatment for MTX-naive, early rheumatoid arthritis (RA) with poor prognostic factors, compared with MTX alone.</div></front></TEI><affiliations><list><country><li>Japon</li><li>Pays-Bas</li></country><region><li>Hollande-Méridionale</li><li>Région de Tōhoku</li></region><settlement><li>Leyde</li><li>Sendai</li><li>Tokyo</li></settlement><orgName><li>Université du Tōhoku</li></orgName></list><tree><country name="Japon"><noRegion><name sortKey="Atsumi, Tatsuya" sort="Atsumi, Tatsuya" uniqKey="Atsumi T" first="Tatsuya" last="Atsumi">Tatsuya Atsumi</name></noRegion><name sortKey="Eguchi, Katsumi" sort="Eguchi, Katsumi" uniqKey="Eguchi K" first="Katsumi" last="Eguchi">Katsumi Eguchi</name><name sortKey="Ishiguro, Naoki" sort="Ishiguro, Naoki" uniqKey="Ishiguro N" first="Naoki" last="Ishiguro">Naoki Ishiguro</name><name sortKey="Iwamoto, Masahiro" sort="Iwamoto, Masahiro" uniqKey="Iwamoto M" first="Masahiro" last="Iwamoto">Masahiro Iwamoto</name><name sortKey="Kita, Yasuhiko" sort="Kita, Yasuhiko" uniqKey="Kita Y" first="Yasuhiko" last="Kita">Yasuhiko Kita</name><name sortKey="Koike, Takao" sort="Koike, Takao" uniqKey="Koike T" first="Takao" last="Koike">Takao Koike</name><name sortKey="Matsubara, Tsukasa" sort="Matsubara, Tsukasa" uniqKey="Matsubara T" first="Tsukasa" last="Matsubara">Tsukasa Matsubara</name><name sortKey="Miyasaka, Nobuyuki" sort="Miyasaka, Nobuyuki" uniqKey="Miyasaka N" first="Nobuyuki" last="Miyasaka">Nobuyuki Miyasaka</name><name sortKey="Okada, Toshiyuki" sort="Okada, Toshiyuki" uniqKey="Okada T" first="Toshiyuki" last="Okada">Toshiyuki Okada</name><name sortKey="Origasa, Hideki" sort="Origasa, Hideki" uniqKey="Origasa H" first="Hideki" last="Origasa">Hideki Origasa</name><name sortKey="Shoji, Toshiharu" sort="Shoji, Toshiharu" uniqKey="Shoji T" first="Toshiharu" last="Shoji">Toshiharu Shoji</name><name sortKey="Takeuchi, Tsutomu" sort="Takeuchi, Tsutomu" uniqKey="Takeuchi T" first="Tsutomu" last="Takeuchi">Tsutomu Takeuchi</name><name sortKey="Tanaka, Yoshiya" sort="Tanaka, Yoshiya" uniqKey="Tanaka Y" first="Yoshiya" last="Tanaka">Yoshiya Tanaka</name><name sortKey="Watanabe, Akira" sort="Watanabe, Akira" uniqKey="Watanabe A" first="Akira" last="Watanabe">Akira Watanabe</name><name sortKey="Yamamoto, Kazuhiko" sort="Yamamoto, Kazuhiko" uniqKey="Yamamoto K" first="Kazuhiko" last="Yamamoto">Kazuhiko Yamamoto</name><name sortKey="Yamanaka, Hisashi" sort="Yamanaka, Hisashi" uniqKey="Yamanaka H" first="Hisashi" last="Yamanaka">Hisashi Yamanaka</name><name sortKey="Yamanishi, Yuji" sort="Yamanishi, Yuji" uniqKey="Yamanishi Y" first="Yuji" last="Yamanishi">Yuji Yamanishi</name><name sortKey="Yasuda, Shinsuke" sort="Yasuda, Shinsuke" uniqKey="Yasuda S" first="Shinsuke" last="Yasuda">Shinsuke Yasuda</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Van Der Heijde, Desiree" sort="Van Der Heijde, Desiree" uniqKey="Van Der Heijde D" first="Désirée" last="Van Der Heijde">Désirée Van Der Heijde</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix 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